Literature summary extracted from

Badugu, R.; Garcia, M.; Bondada, V.; Joshi, A.; Geddes, J.W.
N terminus of calpain 1 is a mitochondrial targeting sequence (2008), J. Biol. Chem., 283, 3409-3417.

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.22.52	mitochondrion	both calpain 1 and calpain small subunit 1, which together form mu-calpain, are present in the mitochondrial intermembrane space. The N-terminus of calpain 1 is not processed following mitochondrial import, but is removed by autolysis following calpain activation. Calpain small subunit 1 is not directly imported into mitochondria, but is imported in the presence of calpain 1. The presence of a mitochondrial targeting sequence in the N-terminal region of calpain 1 is consistent with the localization of mu-calpain to the mitochondrial intermembrane space	Homo sapiens	5739	-
3.4.22.52	mitochondrion	both calpain 1 and calpain small subunit 1, which together form mu-calpain, are present in the mitochondrial intermembrane space. The N-terminus of calpain 1 is not processed following mitochondrial import, but is removed by autolysis following calpain activation. Calpain small subunit 1 is not directly imported into mitochondria, but is imported in the presence of calpain 1. The presence of a mitochondrial targeting sequence in the N-terminal region of calpain 1 is consistent with the localization of mu-calpain to the mitochondrial intermembrane space	Rattus norvegicus	5739	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.52	Homo sapiens	-	-	-
3.4.22.52	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.52	cerebral cortex	-	Rattus norvegicus	-
3.4.22.52	SH-SY5Y cell	neuroblastoma	Homo sapiens	-

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Release 2023.1 (January 2023)